In 1960s San Francisco, bright and talented catholic school girl Celina Guerrera survives a difficult home life by following the rules. That is until an indiscretion creates a series of devastating consequences. As Celina faces the compounded obstacles of being young and alone, she sets out to rise above the oppression of poverty and invest in a future that sets new precedents for the time.

Set in the unique beauty of Oklahoma country, "Dome of Heaven" is the story of the Moses family, dysfunctionally struggling for decades, and which consists of a Cherokee father and German mother and their two adult children Franklin and Flutie. With challenges both personal and societal, each tries to find their place in a world and peace with each other, but so many complications of emotions, culture clash and misunderstanding often keeps them apart.

Following the gruesome murder of a young woman in her neighborhood, an English teacher living in New York City — as if to test the limits of her own safety —propels herself into an impossibly risky sexual liaison with a police detective.