A radio journalist and his technician get in over their heads when they hatch a scheme to fake their own kidnapping during a rebel uprising in South America and hide out in New York instead.

After saving the life of the President, two secret service agents - Myka Bering and Pete Lattimer - find themselves assigned to the top secret Warehouse 13. The Warehouse is a massive, top secret facility that houses dangerous and fantastical objects. Together, Pete and Myka along with fellow agents Claudia, Steve Jinks and Warehouse caretaker Artie, must recover artifacts from around the globe before they can cause catastrophic damage.

Major real-life air disasters are depicted in this series. Each episode features a detailed dramatized reconstruction of the incident based on cockpit voice recorders and air traffic control transcripts, as well as eyewitnesses recounts and interviews with aviation experts.