Kay and Jay reunite to provide our best, last and only line of defense against a sinister seductress who levels the toughest challenge yet to the MIB's untarnished mission statement – protecting Earth from the scum of the universe. It's been four years since the alien-seeking agents averted an intergalactic disaster of epic proportions. Now it's a race against the clock as Jay must convince Kay – who not only has absolutely no memory of his time spent with the MIB, but is also the only living person left with the expertise to save the galaxy – to reunite with the MIB before the earth submits to ultimate destruction.

John Anderton is a top 'Precrime' cop in the late-21st century, when technology can predict crimes before they're committed. But Anderton becomes the quarry when another investigator targets him for a murder charge.

Widower and professor Porter Waide has his life turned upside down with the arrival of his football player brother, Bobby, who's gotten into so much trouble that he's been contracted to live with a responsible relative. This move also disrupts the lives of Porter's impressionable son, Oscar, and Bobby's perpetually annoyed agent, Dena.