Prince Akeem Joffer is set to become King of Zamunda when he discovers he has a son he never knew about in America – a street savvy Queens native named Lavelle. Honoring his royal father's dying wish to groom this son as the crown prince, Akeem and Semmi set off to America once again.

After a disease kills 98% of America's children, the surviving 2% develop superpowers and are placed in internment camps. A 16-year-old girl escapes her camp and joins a group of other teens on the run from the government.

Uncle Drew recruits a squad of older basketball players to return to the court to compete in a tournament.