Duffy, the big man on campus, is marrying Adriana, a debutante heiress to a global wine fortune, right after they both graduate from the same prestigious university. Unfortunately, the final frat party of his college career is the night before his wedding, and there are many obstacles in his way, including a soon to be father-in-law who is less than happy with his daughter's choice.

"The Attackman" refers to the players on a Lacrosse team positioned to score the most points in this aggressive sport. And Lacrosse means everything to Jordan Simms and Chris Wheatley, two high-school seniors from different religious traditions who come to realize, as a life-changing game nears, that their parents' values aren't the same as their own.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.