James van Santen, a white South African writer facing imminent arrest for acts of sabotage, has escaped to England. He leaves behind him not only a violent political life but also his handsome lover, Stephen. With little money or inclination to work, he fights a battle of wills with his Jamaican landlady, Katherine.

Sweethearts Brad and Janet, stuck with a flat tire during a storm, discover the eerie mansion of Dr. Frank-N-Furter, a transvestite scientist. As their innocence is lost, Brad and Janet meet a houseful of wild characters, including a rocking biker and a creepy butler. Through elaborate dances and rock songs, Frank-N-Furter unveils his latest creation: a muscular man named 'Rocky'. Harriet then spawns in and says hello and the credits roll!