In the year 2517, after the arrival of humans in a new star system, follow the adventures of the renegade crew of Serenity, a "Firefly-class" spaceship. The ensemble cast portrays the nine characters who live on Serenity.

Into every generation a slayer is born: one girl in all the world, a chosen one. She alone will wield the strength and skill to fight the vampires, demons, and the forces of darkness; to stop the spread of their evil and the swell of their number. She is the Slayer.

Reverend Eric Camden and his wife Annie have always had their hands full caring for seven children, not to mention the friends, sweethearts and spouses that continually come and go in the Camden household.

Dr. Hugo (Vondie Curtis-Hall) makes house calls, and makes all the young ladies swoon as they see him passing by. If he's not careful, he could find himself in big trouble.