The series revolves around the life of Camilo and Juancho, two friends who work in the maestro Guzmán's orchestra, both share the dream of one day becoming the most recognized musicians in the tropical genre. In this long journey to fulfill their dream, they meet Daniela, a woman of good economic position who wants to be famous and live music as they do. Daniela will have to hide from her family that she is part of a musical orchestra, and Camilo and Juancho that she is from a family of high social class. But everything gets complicated when Camilo and Juancho fall in love with Daniela, that's when their friendship and dreams of being famous will be truncated by the love of a woman.

A small town in the south is ravaged by a serial killer, with everyone being a suspect including the police.