During the summer of 1981, a group of friends in New York are completely unprepared for the onslaught of AIDS. What starts as a rumor about a mysterious "gay cancer" soon turns into a major crisis as, one by one, some of the friends begin to fall ill, leaving the others to panic about who will be next. As death takes its toll, the lives of these friends are forever redefined by an unconditional display of love, hope and courage.

Thirty-something Isabelle spends her time going from her tiny, solitary West Side apartment to that of her grandmother on the Lower East Side. While her grandmother plots to find her a romantic match, Isabelle is courted by a married, worldly author, Anton, yet can't seem to shake the down-to-earth appeal of Sam, a pickle vendor.