Estranged from his father, college student Jake is lured home to New York for Christmas with the promise of receiving a classic Porsche as a gift. When the bullying football team dumps him in the desert in a Santa suit, Jake is left without identification or money to help him make the journey. Meanwhile, his girlfriend, Allie, does not know where he is, and accepts a cross-country ride from Jake's rival, Eddie.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.