Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.

Humanity must resume its war against the Martians when they revive after decades of hibernation following their defeat in the 1950s. The fate of Earth may very well rest in the hands of a small yet courageous band: astrophysicist Harrison Blackwood, paraplegic computer wizard Norton Drake, microbiologist Suzanne McCullough and military man Paul Ironhorse.