Lyra is an orphan who lives in a parallel universe in which science, theology, and magic are intertwined. Her search for a kidnapped friend uncovers a sinister plot involving stolen children and turns into a quest to understand a mysterious phenomenon called Dust. She is later joined on her journey by Will, a boy who possesses a knife that can cut windows between worlds. As she learns the truth about her parents and her prophesied destiny, the two young people are caught up in a war against celestial powers that ranges across many worlds.

A down-and-out DJ plots to rebuild his music career while working as a nanny for his famous best friend's wild 11-year-old daughter.