Joel Barish, heartbroken that his girlfriend underwent a procedure to erase him from her memory, decides to do the same. However, as he watches his memories of her fade away, he realises that he still loves her, and may be too late to correct his mistake.

Katherine Watson is a recent UCLA graduate hired to teach art history at the prestigious all-female Wellesley College, in 1953. Determined to confront the outdated mores of society and the institution that embraces them, Katherine inspires her traditional students, including Betty and Joan, to challenge the lives they are expected to lead.

Fired from his band and hard up for cash, guitarist and vocalist Dewey Finn finagles his way into a job as a fifth-grade substitute teacher at a private school, where he secretly begins teaching his students the finer points of rock 'n' roll. The school's hard-nosed principal is rightly suspicious of Finn's activities. But Finn's roommate remains in the dark about what he's doing.