Cesare Proietti is the esteemed manager of the Relais Colombo, a luxury hotel in Milan. When a group of new Chinese business partners want to revolutionize everything, the hotel owner's daughter, Luciana, decides to fire Cesare. When Cesare discovers Luciana is looking for a caregiver who can look after her father, he decides to dress up as a charming woman to apply for the role.

Miami is one of the most sought by young Italians. It is there, in fact, is going to study at university Luca, a Roman, the son of John and Valentina, Milan, daughter Olivia. During the plane trip from Rome to Miami, Olivia and John argue furiously.

Marco encounters his ex-girlfriend Consueloand starts seeing her without telling that he has just married. Antonio is an MP and during his European trip he has a love affair with elegant Olga who has a big secret to hide. Recently-jilted Fabio is mistaken for psychiatrist by a beautiful girl Valentina with whom he falls in love. A divorce lawyer Sandra is romantically attracted to her client's husband Massimo.

The back-in-time misadventures of Walter and Ascanio are not finished. The defective time-travel machine will bring them from prehistory all the way to outer space, in a funny, light-hearted trip across the time.