Four sixty-something disgraced comedians - who used to work together - find themselves in a retirement home. They'll join forces again, this time to save the place from bankruptcy.

The young priest Father Giulio returns to Rome, his hometown, after a long pilgrimage. Don Giulio hopes to live peacefully with his family and his friends, but discovers that many of them are depressed or frustrated, and some suicidal.

Michele criticizes the film industry and its inhabitants, and is particularly embattled with a Neapolitan director making a musical about the 1968 student demonstrations. At the same time, Michele has a creative block and struggles to finish his film titled "Freud’s Mother." Nanni Moretti’s self-inquiry into filmmaking, political ennui, and men’s relations with their mothers.