When architect-turned-recluse Bernadette Fox goes missing prior to a family trip to Antarctica, her 15-year-old daughter Bee goes on a quest with Bernadette's husband to find her.

Daisuke Yuge works as a tour guide in Oahu, Hawaii and also studies astronomy. He meets Rui Fujishima at a cafe and falls in love with her at first sight, but Rui Fujishima suffers from memory loss due to a past accident.

Three years after the zombie virus has gutted the country, a team of everyday heroes must transport the only known survivor of the plague from New York to California, where the last functioning viral lab waits for his blood.