When a large Iranian-American family gathers in New York City for the patriarch’s heart transplant, a family secret is uncovered and catapults the estranged mother and daughter into an exploration of the past.

When the most important friend in her life seems to have disappeared without a trace, Elena Greco, a now-elderly woman immersed in a house full of books, turns on her computer and starts writing the story of their friendship.

Professor Biondi is a depressed scientist. After his wife's death, he lives isolated from the world in the Nevada desert, near Area 51. He supposedly works on a top-secret project for the US government, but in actuality, he spends his days on the couch, listening to the sound of the Universe. His only contact with the outside world is Stella, who organizes alien-themed weddings for tourists on the prowl for extra-terrestrials. One day the Professor receives a message from Naples: his dying brother is entrusting him with his two children, so that they may live with him in America.