In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.

The office politics and interpersonal relationships among the staff of WNYX NewsRadio, New York's #2 news radio station.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.

Pat Riley, an obnoxious busybody of indeterminable sex, meets and falls in love with Chris, a sensitive, caring person also of indeterminable sex. Their relationship suffers because Pat's a lout, and cannot decide on a direction for their life. Meanwhile, Pat's neighbor Kyle falls further and further into obsession with Pat, fascinated by their indeterminate sexuality.

Martha Horgan is a withdrawn, mentally disabled woman who lives with her aunt, Frances. One of Martha's unusual traits is that she doesn't lie, a quality that leads to her getting fired from a dry-cleaning shop thanks to the actions of the shifty Getso. Conflict seems to follow Martha, since she also becomes romantically involved with local fix-it man, Mackey, who is sleeping with Frances as well.

Theorizing that one could time travel within his own lifetime, Dr. Sam Beckett stepped into the Quantum Leap accelerator and vanished... He woke to find himself trapped in the past, facing mirror images that were not his own and driven by an unknown force to change history for the better. His only guide on this journey is Al, an observer from his own time, who appears in the form of a hologram that only Sam can see and hear. And so Dr. Beckett finds himself leaping from life to life, striving to put right what once went wrong and hoping each time that his next leap will be the leap home.