Three strangers share an obsession with true crime and suddenly find themselves wrapped up in one.

The story of Steve Harmon, a 17-year-old honor student whose world comes crashing down around him when he is charged with felony murder.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.