A reporter witnesses a brutal murder, and becomes entangled in a mystery involving a pair of Siamese twins who were separated at birth, one of them forced to live under the eye of a watchful, controlling psychiatrist.

A student's premonition of a deadly rollercoaster ride saves her life and a lucky few, but not from death itself – which seeks out those who escaped their fate.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.