Until the 1970s, Italian cinema dominated the international scene, even competing with Hollywood. Then, in just a few years, came its rapid decline, the flight of our greatest producers, a crisis among the best writer-directors, the collapse of production. But what are the true causes and circumstances of this decline? In an attempt to provide an answer to this question, Di Me Cosa Ne Sai strives to depict this great cultural change. Begun as a loving examination of Italian cinema, the film transformed into a docu-drama that alternates between interviews with the great names of the past and fragments of cultural and political life of the last 30 years. It is a travel diary that shows Italy from north to south, through movie theatres; television-addicted kids; Berlusconi and Fellini; shopping centers; TV news editors; stories of impassioned film exhibitors and directors who fight for their films; and interviews with itinerant projectionists and great European directors.

Dante arrives at the castle of the recently deceased Marquis Zanetti to sell a book which contains a prophecy that the death of nine members of the Zanetti family will reveal a hidden treasure.

A young restorer is commissioned to save a fresco representing the suffering of St. Sebastiano, which was painted on the wall of a local church by a mysterious, long-dead artist.

Pasqualino Frafuso, known in Naples as "Pasqualino Seven Beauties" is a petty thief who lives off of the profits of his seven sisters while claiming to protect their honor at any cost, Pasqualino is arrested for murder and later sent to fight in the army after committing sexual assault. The Germans capture him and he gets sent to a concentration camp where he plots to make his escape by seducing a German officer.