Ten years after his retirement from the government, Colonel Steve Austin must again team up with Jaime Sommers to stop a terrorist group. Complicating matters for Austin are his estranged son Michael, who struggles for his father's acceptance as he graduates from flight school, and Jaime, who must cope with her and Steve's past. When Michael is severely injured in a crash, Steve must make the same decision about fitting him with bionics that he had to make with Jaime years ago after her accident.

When THRUSH steals a nuclear weapon and demands a ransom delivered by Napoleon Solo, UNCLE recalls him and his partner to duty.

While the prestigious Cannes Film Festival goes on around him, American movie producer Jesse Craig struggles to develop a pitch-worthy thriller about a terrorist plot. Before long, Craig becomes concerned that a shocking act of real-life terrorism already may be underway. Meanwhile, radical actor Bret Easton works in cahoots with a group of extremists to coordinate the hijacking of a trio of passenger planes in a devastating, multi-city nuclear attack.