When the magic powers of The Tablet of Ahkmenrah begin to die out, Larry Daley spans the globe, uniting favorite and new characters while embarking on an epic quest to save the magic before it is gone forever.

After Kick-Ass’ insane bravery inspires a new wave of self-made masked crusaders, he joins a patrol led by the Colonel Stars and Stripes. When these amateur superheroes are hunted down by Red Mist — reborn as The Mother Fucker — only the blade-wielding Hit-Girl can prevent their annihilation.