Growing up in Las Vegas, Danny and Melissa meet at age eight and are destined to become life-long friends. During their teen years, they cling to each other for love and security, but as they grow older, their lives take different paths. Danny fills the void in his heart with his passion and love for America's favorite pastime. Melissa, filled with the insecurities of her youth, struggles to find the strength to pursue her childhood dreams. Although apart, their lives are forever connected. Like a glorious seven-game world series, "Pitcher and the Pin-Up" is a story of imperishable hope, courage, faith, love, and coming home.

Can you tell the difference between fact and fiction? Several stories of strange, mysterious and incredible occurrences are chronicled during each episode. It is up to the viewer to decide which stories actually happened and which were completely fabricated by the show’s writers. The answer is revealed by Jonathan Frakes at the conclusion of each episode.

After the death of his older brother, Guiseppe "the guppy" Calzone becomes head of the Calzone Mob family. His aging father knows his son is not cut out for the job, so he sends him to "Mafia University". The head of a rival Mafia Family sees this as an opportunity to strike and bring the Calzone Family to its knees. Surrounded by danger, double-crossing and pasta.

Damon is a down-on-his-luck commercial photographer scratching for every mundane, boring job he can get just to survive. He discovers that a supernatural power has been gifted to him. When he touches someone, he can see their most intimate sexual fantasy. A whole new world of erotic adventure has opened up to him and his normally stuffy photo sessions turn into orgies of eroticism as his subjects let loose their innermost fantasies.

In his basement in San Francisco, boy-genius Quinn Mallory unlocks the doorway to an infinite number of Earths. During a test run, Quinn invites co-worker Wade Welles and his teacher Professor Maximillian Arturo to see his new invention. But an increase in power and an early departure leave all three, plus a washed-up soul singer named Rembrandt "Crying Man" Brown, lost in a parallel world. Now they must "slide" from world to world, not only adapting to their changing surroundings, but also trying to get back to their world. Will they ever make it home?