In his basement in San Francisco, boy-genius Quinn Mallory unlocks the doorway to an infinite number of Earths. During a test run, Quinn invites co-worker Wade Welles and his teacher Professor Maximillian Arturo to see his new invention. But an increase in power and an early departure leave all three, plus a washed-up soul singer named Rembrandt "Crying Man" Brown, lost in a parallel world. Now they must "slide" from world to world, not only adapting to their changing surroundings, but also trying to get back to their world. Will they ever make it home?

An Irish immigrant and his daughter arrive in Kentucky with a magical piece of gold that alters the course of several lives, including those of a struggling farmer and an African American community facing persecution from a bigoted politician.

Clay Spencer and his wife, Olivia, live in a small town deep in the mountains. When Clay isn't busy drinking with his buddies or railing against the town minister, he's building the house he's always promised Olivia. He is overjoyed when he learns his eldest son will be the first Spencer to attend college, if he can resist the charms of a pretty local girl and rustle up the money for tuition.

Joseph "Doc" Frail is a doctor with a past he's trying to outrun. While in Montana, he comes across a mining camp with a hanging tree and rescues a man named Rune from the noose. With Rune as his servant, Frail decides to settle down, and he takes over as town doctor. He meets Elizabeth, who is suffering from shock, and the two soon fall in love. But when Elizabeth is attacked, Frail's attempt to help her lands them both in trouble.

Ellen McNulty leaves her New Jersey hamburger stand and heads west to pay a surprise visit to her son and his new bride. When Ellen arrives, her daughter-in-law mistakes her for the maid she has hired for a big party they are throwing. Rather than cause any embarrassment, Ellen goes along with the charade, which leads to many complications.