Dr. Tremayne is an enigmatic psychiatrist running an asylum that houses four very special cases. Visited by his colleague Nicholas, Tremayne explains his amazing and controversial theories as to why each of the four patients went mad.

In a near-future Britain, young Alexander DeLarge and his pals get their kicks beating and raping anyone they please. When not destroying the lives of others, Alex swoons to the music of Beethoven. The state, eager to crack down on juvenile crime, gives an incarcerated Alex the option to undergo an invasive procedure that'll rob him of all personal agency. In a time when conscience is a commodity, can Alex change his tune?