A scientist gets into serious trouble after being ridiculed by colleagues over his controversial research into the cognitive capacities of flies. Going slightly crazy, the scientist creates a Frankensteinian monster which is controlled by a maggot in order to prove his theories. Far from being a peaceful and intelligent creature, a violent monstrocity emerges and escapes the lab. Maggot Man is pursued by mad scientists, special police investigators, and even ninja, and leaves a path of destruction in his quest to knock humanity off the top of the food chain.

When the body of the executive of hockey Benoit Brisset is found on the billboard of the border of Quebec and Ontario, the jurisdiction of the crime is shared between the two police forces and detectives David Bouchard from Montreal and Martin Ward from Toronto are assigned to work together. With totally different styles, attitudes and languages.