The old and overcrowded penitentiaries are just a memory. Inmates now serve their sentence in a state of deep sleep that renders them harmless, and has drastically reduced recidivism. Until one day, a psychologist in charge of monitoring the mental state of inmates finds himself confronted with a prisoner over whom he's lost all control.

Six aspiring comedians tired of the mediocrity of their lives, at the end of an evening stand-up course they prepare to face their first performance in a club. In the audience there is also an examiner, who will choose one of them for a TV show. For everyone this is the great opportunity to change their life, for some it could be the last one. The performances begin and each comedian takes the stage with a great dilemma: to respect the teachings of their master, devoted to intelligent and uncompromising comedy, or to twist their numbers to satisfy the much less refined taste of the examiner? Or maybe look for a third way, one of absolute originality? Through the stories of six comedians, Comedians is a reflection on the very meaning of comedy in our time, facing absolutely topical issues.

Milan, Italy, 1967. Santo Russo, a boy of Calabrian origin, arrives north with his parents and younger brother to find better living conditions. Due to an absurd misunderstanding and his father's contempt, Santo ends up in prison, where he gets a “true education.” In 1978, he and his friends Slim and Mario embark on a 15-year criminal career, a successful and ruthless spiral of robberies, kidnappings, murders and heroin smuggling.