Around 1940, New Yorker staff writer Joe Mitchell meets Joe Gould, a Greenwich Village character who cadges meals, drinks, and contributions to the Joe Gould Fund and who is writing a voluminous Oral History of the World, a record of 20,000 conversations he's overheard. Mitchell is fascinated with this Harvard grad and writes a 1942 piece about him, "Professor Seagull," bringing Gould some celebrity and an invitation to join the Greenwich Village Ravens, a poetry club he's often crashed. Gould's touchy, querulous personality and his frequent dropping in on Mitchell for hours of chat lead to a breakup, but the two Joes stay in touch until Gould's death and Mitchell's unveiling of the secret.

Aging publisher Will Randall is at the end of his rope when a younger co-worker snatches his job out from under his nose. But after being bitten by a wolf, Will suddenly finds himself full of youthful vigor. As he struggles to regain his position, he becomes enthralled with Laura Alden, his former boss's daughter. And, as increasingly animal-like urges begin to overwhelm him, Randall worries that he may be turning into the creature that bit him.