Aging publisher Will Randall is at the end of his rope when a younger co-worker snatches his job out from under his nose. But after being bitten by a wolf, Will suddenly finds himself full of youthful vigor. As he struggles to regain his position, he becomes enthralled with Laura Alden, his former boss's daughter. And, as increasingly animal-like urges begin to overwhelm him, Randall worries that he may be turning into the creature that bit him.

Seeking to raise his credibility as an actor and to land a role as a tough cop on a new show, Hollywood action star Nick Lang works a deal with New York City Police Capt. Brix, who by chance is one of his fans. Nick will be paired with detective Lt. John Moss and learn how to act like a real cop. But when Nick drives John crazy with questions and imitating him, he gets in the way of John's pursuit of a serial killer.

In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

Seen-it-all New York detective Frank Keller is unsettled - he has done twenty years on the force and could retire, and he hasn't come to terms with his wife leaving him for a colleague. Joining up with an officer from another part of town to investigate a series of murders linked by the lonely hearts columns he finds he is getting seriously and possibly dangerously involved with Helen, one of the main suspects.

After witnessing the accidental death of a friend who was attempting to rescue him from bullies, an African-American boy blames himself and, stricken with guilt, hides out among underground street people in New York.