This rock opera tells the story of one year in the life of a group of bohemians struggling in late 1980s East Village, New York, USA. The film centers around Mark and Roger, two roommates. While a tragedy has made Roger numb to new experiences, Mark begins capturing their world through his attempts to make a personal movie. In the year that follows, they and their friends deal with love, loss, and working together.

In 1839, the slave ship Amistad set sail from Cuba to America. During the long trip, Cinque leads the slaves in an unprecedented uprising. They are then held prisoner in Connecticut, and their release becomes the subject of heated debate. Freed slave Theodore Joadson wants Cinque and the others exonerated and recruits property lawyer Roger Baldwin to help his case. Eventually, John Quincy Adams also becomes an ally.