A young artist, imprisoned within the trammels of opium addiction, relives his phantasmagorical courtship with a mysterious Soprano known only as Ligeia. While exploring these opium induced memories, the lines dividing reality and fantasy, memory and hallucination, begin to blur into an indecipherable labyrinth of obsession and despair. Though he is nursed back to health by a new love, the Lady Rowena, the haunting of Ligeia's memories as well as the spirits of Azrael and Nehushtan, continue to plague his mind and soul.

In Knockemstiff, Ohio and its neighboring backwoods, sinister characters converge around young Arvin Russell as he fights the evil forces that threaten him and his family.

Remy LaLonde is working through the difficulties of young love when a hurricane forces him and his long-time girlfriend Natalie Enriquez to evacuate New Orleans. In the process, Remy must leave behind his mother Camilla, who stays in the city to accommodate her father (and Remy's grandfather) Alan Duplessis. While on the outside, the severity of the storm becomes disastrously clear and Remy's communication to Camilla is cut off completely. With no road back to New Orleans, Natalie and Remy must simultaneously navigate their relationship and evacuation.

The life stories of history's greatest minds. From their days as young adults to their final years we see their discoveries, loves, relationships, causes, flaws and genius.