Grand Canyon revolved around six residents from different backgrounds whose lives intertwine in modern-day Los Angeles. At the center of the film is the unlikely friendship of two men from different races and classes brought together when one finds himself in jeopardy in the other's rough neighborhood.

Lilah Krytsick is a mother and housewife who's always believed she could be a stand-up comedian. Steven Gold is an experienced stand-up seemingly on the cusp of success. When the two meet, they form an unlikely friendship, and Steven tries to help the untried Lilah develop her stage act. Despite the objections of her family and some very wobbly beginnings, Lilah improves, and soon she finds herself competing with Steven for a coveted television spot.