Sometime in the 22nd century, humans have fully terraformed and colonized Venus and Mars. The Neosapiens, an artificially engineered race created to be slaves for the Terrans, have turned against their masters and formed the Neosapien Order/Empire/Commonwealth. Under the rule of the calculating Governor General Phaeton, the Neosapiens have launched an invasion of Earth and Venus. The ExoFleet, the Homeworlds' space navy (in particular, Able Squad, a group of Exo-Frame pilots led by Lieutenant J.T. Marsh), fight against the invasion in an interplanetary war to protect the Terrans.

Duncan MacLeod cannot die -- he is a 400-year-old immortal, who has seen his share of humanity's history. Still, he risks his life in battle against other immortals and tries to save people from harm.

He's everyone's favorite action hero... but he's a hero with a difference. Angus MacGyver is a secret agent whose wits are his deadliest weapon. Armed with only a knapsack filled with everyday items he picks up along the way, he improvises his way out of every peril the bad guys throw at him. Making a bomb out of chewing gum? Fixing a speeding car's breaks... while he's riding in it? Using soda pop to cook up tear gas? That's all in a day's adventures for MacGyver. He's part Boy Scout, part genius. And all hero.