Phil and his misfit friends score big when they are invited to the party of the century at Bob's house. Known for throwing the craziest drug, sex and booze filled parties, this was sure to be a night to remember. The only problem is that they can't remember a thing. When Phil wakes up realizing that his girlfriend is only hours from knocking on his door, he decides to enlist the help of his friends to try to piece together what was obviously a night worth remembering.

A depressed musician reunites with his lover in the desolate streets of Detroit. Though their romance has endured several centuries, it is tested by the arrival of her capricious and unpredictable younger sister.