Slick lawyer Thomas Farrell has made a career of defending mobsters in trials. It's not until he meets a lovely showgirl at a mob party that he realizes that there's more to life than winning trials. Farrell tries to quit the racket, but mob boss Rico Angelo threatens to hurt the showgirl if Farrell leaves him.

Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.