The Narrator tells us how the radio influenced his childhood in the days before TV. In the New York City of the late 1930s to the New Year's Eve 1944, this coming-of-age tale mixes the narrator's experiences with contemporary anecdotes and urban legends of the radio stars.

Roberta is a bored suburban housewife who is fascinated with a woman, Susan, she only knows about by reading messages to and from her in the personals section of the newspaper. This fascination reaches a peak when an ad with the headline "Desperately Seeking Susan" proposes a rendezvous. Roberta goes too, and in a series of events involving amnesia and mistaken identity, steps into Susan's life.