As Britain is rocked by unstable political, economic and technological advances, members of the Lyons family converge on one crucial night in 2019. Over the next 15 years, the twists and turns of their everyday lives are explored as we find out if this ordinary family could change the world.

In Liverpool, Joanne Conlon rescues a weeping statue of the Virgin Mary from her local church's replacement plans. As her family faces financial struggles and newfound success, the statue's tears return, turning their lives upside down and drawing crowds from near and far to witness the miraculous phenomenon.

Set during the 1960s in the fictional North Yorkshire village of Aidensfield, this enduringly popular series interweaves crime and medical storylines.