From the Egyptian desert to deep below the polar ice caps, the elite G.I. JOE team uses the latest in next-generation spy and military equipment to fight the corrupt arms dealer Destro and the growing threat of the mysterious Cobra organization to prevent them from plunging the world into chaos.

Physicists Leonard and Sheldon find their nerd-centric social circle with pals Howard and Raj expanding when aspiring actress Penny moves in next door.

Betty Suarez is smart, tough and tenacious, but also sensitive and loving. She hopes these skills will help her to get a job within the Meade Publishing Corporation. The fact that she isn’t traditionally attractive initially keeps her from getting hired by fashion bible, Mode. The magazine, however, is in flux, with power-hungry executives vying for dominance. Hoping to control the situation, the publisher gives his inexperienced son, Daniel, the position of Editor-in-Chief. He hires Betty as Daniel’s assistant after catching him in a compromising position with his secretary on his first day on the job. After a tough start, in which Daniel tries to force Betty into quitting by treating her terribly, he realizes her worth and the two pair up to be an effective team.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.