The blood orchid - a rare flower that could hold the secret of eternal life and be worth a fortune to the company that finds it first. Led by a pharmaceutical research team, a scientific expedition sets out to go and explore deep into the jungles of Borneo to locate and bring back samples of the legendary plant. Battling through rainstorms to make their way upriver, the group encounters poisonous insects and a ferocious crocodile, only to discover they're being stalked by an even greater danger: a gathering of giant anacondas. Heat-sensing, fifty-foot-long flesh eaters that will go after anyone that crosses in their path.

Based on Louis L'Amour novel, The Diamond of Jeru tells the story of an American scientist and his wife who hire an ex-pat war veteren to act as a guide on a journey up an unchartered Borneo river in search of diamonds.