Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Young, innocent, and quirky June (Felicia Day), a violinist, spends her days working in an oddball Venice coffee shop, her nights rehearsing for a professional music career, and all-hours daydreaming about the beautiful man that's destined just for her. When she actually meets him in her own apartment building, she finds out Jack (Chris Henry Coffey) is engaged to the quintessential gorgeous bitch, Quinn (Cindy Dolenc). The conflict ensues and the romance is tested. Whether it's indulging her loony Grandma (Ellen Geer) through rehearsals of her own funeral, or dealing with the overzealous video-store manager (Ted Michaels) and his crush, June stumbles through her potential love life, her best friend Mary at her side.

On her sixteenth birthday, Sabrina Spellman discovers she has magical powers. She lives with her 600-year-old aunts Hilda and Zelda as well as talking cat Salem in the fictional town of Westbridge, Massachusetts.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.