Angela and Franca decide to take the dream trip of their lives. They run away from their boring retirement home in Rome and make a daring getaway to fabulous Venice in this joyous, heart-warming on-the-road adventure where anything can – and does – happen.

Follows a criminal gang in Rome that has a near monopoly of the city's heroin trade. Besides their internal feuding, the gang has to deal with the Camorra and Sicilian Mafia that both supply its heroin, the police led by Commissioner Scialoja and the Italian secret services.

Irene, a workaholic, is forced to re-evaluate her priorities after the suicide of her two best friends.

Rome, 1929. The Pope's tailor sends his only son, 35-year-old virgin Nello, to more liberal Bologna hoping he'll find a wife. His head brimming with ideas on romantic love induced by classical poetry, Nello falls for Angela, a beautiful blind woman who indulges him only to win back her fiancé.

Leonardo is a young theater enthusiast who has written a comedy for a comedian at sunset, Giordani, and leaves for the Adriatic coast together with the producer Peppino and his assistant to reach the actor and convince him to stage the script. During the journey, which becomes longer and longer and with unusual and bizarre stops, he will soon realize that Peppino's attentions are not disinterested, while he will be attracted by a young and beautiful girl, Paola.

Armando Andreoli, a well-known engineer of almost 80 years, is approached by Federica, an assistant nurse who then invites him to his hotel room. In the morning, Federica's boyfriend arrives in the room, suspecting a relationship that has never existed.