In this sequel, Lillian has been adopted and it's several years later. Annie, married and pregnant, visits her fellow doctor friend, Dr. Owen. Dr Owen desperately wants a baby, but seems unable to become pregnant. Lillian finds a love interest, an assistant to her adoptive dad, the latter has become quite overprotective.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.