Erwin, a girl genius, is the youngest student in high school. Unfortunately she struggles with social isolation. When she meets fellow science guru, Winston, they team up to invent a chemical that changes the high school hierarchy forever.

Lifelong friends Maddie, Helen and Dana Sue lift each other as they juggle relationships, family and careers in the small, Southern town of Serenity.

Leo Borlock is an average student at Mica High School. He gets decent grades, is a member of the school's marching band and has always been content flying under the radar. But all that changes when he meets Stargirl Caraway, a confident and colorful new student with a penchant for the ukulele, who stands out in a crowd. She is kind, finds magic in the mundane and touches the lives of others with the simplest of gestures. Her eccentricities and infectious personality charm Leo and the student body, and she quickly goes from being ignored and ridiculed to accepted and praised, then back again, sending Leo on a rollercoaster ride of emotions.

Earl Stone, a man in his eighties, is broke, alone, and facing foreclosure of his business when he is offered a job that simply requires him to drive. Easy enough, but, unbeknownst to Earl, he's just signed on as a drug courier for a Mexican cartel. He does so well that his cargo increases exponentially, and Earl hit the radar of hard-charging DEA agent Colin Bates.

Carmilla inadvertently infects Ron, Fang, and Corey with her vampirism. Unaware of their condition, these three misfit vampires' hysterical misadventures illuminate the sudden changes in their nature. While attending a support group recommended by Dr. Acula for what is thought to be a medical condition, the three connect back with Carmilla and learn the truth of their new existence. Cast out by Martin and the old vampires, pursued by the determined Eddie Van Helsing, Ron and Carmilla seek to maintain some humanity and lead their menage through the challenges of vampire life in the modern world.

After North Jackson High's long-time principal steps down to tend to his ailing wife, Neal Gamby and Lee Russell, the school's vice principals, are forced to put their mutual disdain aside and form an unholy alliance in order to sabotage the newly appointed principal, Dr. Belinda Brown.