Harvard symbologist Robert Langdon is recruited by the Vatican to investigate the apparent return of the Illuminati - a secret, underground organization - after four cardinals are kidnapped on the night of the papal conclave.

An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.