The Bandit goes on another cross-country run, transporting an elephant from Florida to Texas. And, once again, Sheriff Buford T. Justice is on his tail.

Wendell Lawson has only six months to live. Not wanting to endure his last few months of life waiting for the end, he decides to take matters into his own hands and enlists the help of a delusional mental patient to help him commit suicide.

After his release from prison, notorious ex-con and moonshine distiller Gator McKlusky moves in with his father in a cabin in the Okefenokee Swamp. His bootlegging plans are cut short, however, when a federal agent tells McKlusky that he will lose custody of his 9-year-old daughter unless he helps bring down local crime lord Bama McCall. McKlusky enlists the help of reporter Aggie Maybank and a few local eccentrics to bring down McCall's empire.