After winning an all-expenses-paid Mardis Gras vacation in New Orleans, a tight-knit group of college friends prepare for the time of their lives. But boobs, beads and debauchery get pushed to the back burner when murder bubbles up to the surface. A local tourist trap hawking voodoo trinkets seems to be the source of all the trouble, but no one's sure who's pulling the strings when it comes to orchestrating the killings.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.