In the distant future, Earth is occupied by ancient gods and genetically altered humans. When a god is sentenced to death he seeks a new human host and a woman to bear his child.

Sydney Fox is a professor and globe-trotting "relic hunter" who looks for ancient artifacts to return to museums and/or the descendants of the original owner. She is aided by her linguistic assistant Nigel and occasionally by her somewhat air-headed secretary Claudia. She often ends up battling rival hunters seeking out artifacts for the money.