In 1979 Ohio, several youngsters are making a zombie movie with a Super-8 camera. In the midst of filming, the friends witness a horrifying train derailment and are lucky to escape with their lives. They soon discover that the catastrophe was no accident, as a series of unexplained events and disappearances soon follows. Deputy Jackson Lamb, the father of one of the kids, searches for the terrifying truth behind the crash.

Follows the personal and professional lives of a group of doctors at Seattle’s Grey Sloan Memorial Hospital.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.