The Secrets of Isis is the syndicated title of a live action CBS television series produced by Filmation in the 1970s originally titled Isis that appeared during the Saturday morning cartoon lineup. The show was also aired in various countries around the world. As indicated on commentary in the 2007 DVD release of the series, and supported by examining broadcast premiere dates, The Secrets of Isis was the first weekly American live-action television series whose lead character was a female superhero, debuting September 6, 1975 and predating the weekly debuts of both The Bionic Woman and Wonder Woman.

The Invaders, alien beings from a dying planet. Their destination: the Earth. Their purpose: to make it their world. David Vincent has seen them, for him it began one lost night on a lonely country road, looking for a shortcut that he never found. It began with a closed deserted diner, and a man too long without sleep to continue his journey. It began with the landing of a craft from another galaxy. Now, David Vincent knows that the Invaders are here, that they have taken human form. Somehow he must convince a disbelieving world that the nightmare has already begun.

A housewife's sudden rise to fame as a soap spokesperson leads to chaos in her home life.